Perspectives on cancer management
نویسنده
چکیده
Alan So, MD, FRCSC is a Urologic Oncology Fellow in the Faculty of Medicine, University of British Columbia / Vancouver Hospital – Vancouver Coastal Health Research Institute. S. Larry Goldenberg, MD, FRCSC, FACS is Director of The Prostate Centre at Vancouver General Hospital, and Professor and Head, Division of Urology, University of British Columbia. Address for correspondence: Dr. S. Larry Goldenberg, 2660 Oak Street, Vancouver, BC, V6H 3Z6; Tel: (604) 875-5006; Fax: (604) 875-5604. The introduction of prostate-specific antigen (PSA) into the paradigm of early detection has resulted in a stage migration towards more localized, and curable, prostate cancers. This has led, however, to an unfortunate trend to over-diagnosis and over-treatment of biologically insignificant disease. One challenge we face in the modern PSA era is to differentiate men who have disease destined to progress and cause morbidity/mortality from those who will not require immediate, or possibly even delayed, therapeutic intervention. Researchers are attempting to develop a prognostic marker of some type — via molecular, biochemical, imaging and other routes — that will be able to meet this challenge.
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